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Treatment Name: |
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Radiation Therapy and Stereotactic Radiosurgery With or Without Temozolomide or Erlotinib in Treating Patients With Brain Metastases Secondary to Non-Small Cell Lung Cancer |
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Phase: |
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Phase 3 |
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Treatment ID#: |
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1604 NCT00096265 |
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Age Group: |
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Adults Only |
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Min Karnofsky Score: |
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70: Cares for self, unable to perform normal activity or to do active work |
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Conditions: |
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Prior Surgery is Allowed
Prior Radiation is Sometimes Allowed
Prior Chemotherapy is Allowed
Histologically confirmed non-small cell lung cancer
One to 3 intraparenchymal brain metastases by contrast-enhanced MRI, meeting the following criteria:
Well circumscribed tumor(s)
Maximum diameter = 4.0 cm
If multiple lesions are present and one lesion is at the maximum diameter, the other lesions must be = 3.0 cm in maximum diameter
No metastases within 10 mm of the optic apparatus such that a portion of the optic nerve or chiasm would be included in the high-dose stereotactic radiosurgery boost field
No metastases in the brainstem, midbrain, pons, or medulla
No prior complete resection of all known brain metastases
Subtotal resection allowed provided residual disease is = 4.0 cm in maximum diameter
No clinical or radiographic evidence of progression (other than study lesion[s]) within the past month
Patients with brain metastases at initial presentation do not require 1 month of scans documenting stable disease
Stable extracranial metastases allowed
Extent of extracranial metastases documented by contrast-enhancing CT scans of the chest, abdomen, and pelvis AND bone scan
No liver metastases
No leptomeningeal metastases by MRI or cerebrospinal fluid evaluation
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Last Updated: |
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05/01/2007 |
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Tumor Types: |
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Metastatic Brain Tumor |
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Comments: |
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Treatment Type: |
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Chemotherapy
Radiation |
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Contact: |
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John Suh MD
Cleveland Clinic Brain Tumor and Neuro-Oncology Center
Contact: Renee Yorkievitz
9500 Euclid Ave
Cleveland, OH 44195 USA
Phone: 216-445-6545
Fax:
E-mail: yorkier@ccf.org
Website: |
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- Last updated refers to the date when our listing for each treatment was last updated.
- ID is a combination of our internal ID and the official ID for the trial, if any.
- Min Karnofsky is a general guide to how well you have to function to use this treatment
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