Details For Selected Brain Tumor Treatment

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Last updated refers to the date when our listing for each treatment was last updated.
ID is our internal ID - starting with VT.
Min Karnofsky is a general guide to how well you have to function to use this treatment
For trials that also have a NCT number, you can click that number to pop up the listing from the clinicaltrials.gov website.

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		Treatment Name:		2009-0476: A Phase I dose-finding study of XL184 administered orally in combination with Temozolomide and Radiation Therapy in first line treatment of glioblastoma

		Keywords:		XL184, Temozolomide, radiation therapy

		Phase:		Phase 1

		Treatment ID#s:		VT1947 2009-0476

		Age Group:		Adults Only

		Min Karnofsky Score:		70: Cares for self, unable to perform normal activity or to do active work

		Conditions:		Newly Diagnosed: Y Recurrent: N Prior Surgery is Allowed Prior Radiation is Not Allowed Prior Chemotherapy is Sometimes Allowed Glioblastoma, gliosarcoma diagnosed after partial or complete resection, with adequate archival or fresh tumor tissue from resection

		Last Updated:		03/30/2010

		Tumor Types:		Glioblastoma Multiforme


		Comments:		The addition of XL184 , targeting the c-MET pathway may potentiate the response of glioblastoma tumors to radiation therapy, and may also decrease side effects from radiation therapy because of its anti-angiogenic effect. Available evidence suggests minimal potential for the addition of XL184 to interfere with temozolomide activity.

		Treatment Type:		Chemotherapy Radiation.

		Contact:		MD Anderson Cancer Center Jan Esenwein Program Coordinator, Brain Tumor Program Contact: Jan Esenwein or Marie Woodward 1515 Holcombe Blvd Houston, TX 77030- Phone:(713)745-2264 Fax: (713)794-4999 Click here to send an email Website: www.mdanderson.org/diseases/braincancer/

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